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cross-referenced data from two large-scale SZ GWAS studies [110, 124] with scRNAseq data from the adult mouse brain, and they found significant enrichment for SZ risk genes in hippocampal CA1 pyramidal neurons, medium spiny neurons (MSNs), striatal PV-expressing interneurons and somatosensory pyramidal neurons from cortical layers 2/3, 4, 5 and 6 [140]
doi: 10.1038/sj.onc.1205240 180 HagelgansANackeBZamaraevaMSiegertGMenschikowskiM
Pregnant or breastfeeding women should avoid MOTS-c given the absence of safety data in these populations, as is standard for all investigational peptide therapies
To the contrary, high to normal levels of circulating IGF-1 correlate with a rise in adiponectin levels and a reduced prevalence of MetS is found [233]
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