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We cant assume that patients will get worsening eye disease while on these drugs, says Dr
It acts through G-protein coupled GLP-1 receptors (GLP-1R), that act via the activation of adenylyl cyclase (Drucker et al., GLP-1 analogs can decrease apoptosis, increase cell viability, neurogenesis, reduce inflammation, and decrease oxidative stress
Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]
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