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That same remodeling activity is why an aggressive routine can temporarily make skin look worse before it looks better

The triggers of cellular senescence include but are not limited to telomeric erosion, induction of the DNA damage response, epigenetic changes, genomic instability, mitochondrial dysfunction, reactive metabolites, oxidative stress, inactivation of certain tumor suppressor genes, oncogenic and therapy-induced stress, and viral infections (Narita et al., 2003

The GLP-1R/GIPR dual-agonist tirzepatide has demonstrated a remarkable 23% body weight reduction in individuals with obesity over 72 weeks, eclipsing the average result achieved by certain bariatric surgery [78]

Poor sleep is not considered a common or expected side effect of GLP1 agonists such as Wegovy or Mounjaro