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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

This article walks through why the 1:1 design makes sense, what the equal-proportion choice delivers compared to non-standard ratios, and when the standard formulation is the right tool

Maintaining a nutrient-rich diet can further enhance results

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