iron and glutathione Consequences of exposure depletion on redox balance, lipidome, and neurotransmission in C. elegans Heavy Metal Detox: Can Glutathione

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NMR in Biomedicine, 31(1)

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The resulting no-reflow phenomenonwherein tissue perfusion remains inadequate despite macrovascular restorationexacerbates hypoxia and creates a self-amplifying cycle of inflammation, mitochondrial damage, and microcirculatory failure ( 2.2.2 mtDAMPs release and SIRS-like systemic inflammation A pivotal consequence of IR-induced mitochondrial damage is the amplification of mtDAMPs release into the extracellular space and systemic circulation