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In addition, chimeric GLP-2 whose C-terminal fragment (residues 2033) was replaced with that of GLP-1 displayed a 17-fold potency reduction in GLP-2R signaling but successfully elicited GLP-1R-mediated cAMP accumulation (Fig
are supported by the UCLH NIHR BRC
Its demonstrated small effects on body weight and body fat by otherwise minimal impact on other metabolic markers as shown in humans make it a proper sugar replacer, potentially useful in weight management
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