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Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8
Some of the symptoms which characterize the inherited disease are mimicked by the administration of drugs interacting with OCTN2 as off-target or by some diet regimens (Pochini et al., 2009, 2019
Endothelial nitric oxide is also involved in cognitive function and protection against neurodegenerative diseases
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The 4-phosphopantetheine group also functions in the context of the folate cycle via the cytosolic ALDH1L1 (aldehyde dehydrogenase 1 family member L1) encoded enzyme and the functionally related mitochondrial ALDH1L2
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