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MOTS-c is known to stimulate AMP-activated protein kinase (AMPK) ( The dual mitochondrial/nuclear localization is also shown for SHLP 2 and 3, whereas SHLP 1, 4, 5, and 6 are located exclusively in the mitochondria (Thiankhaw et al., 2022)
It holds particular promise for ME/CFS and fibromyalgia patients, especially those struggling with fatigue, brain fog, and nerve pain
In these cases, immune regulation and gut health should come first
Consult with a qualified healthcare provider before starting any supplementation or hormone therapy program
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