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However, the relevance of DISC1 mutation in SZ pathology is debatable, as this gene does not appear to be a clear genetic risk factor for SZ in newer GWAS or exome sequencing studies

SCFAs signal through dedicated G-protein-coupled receptors (FFAR2, FFAR3, HCAR2) on enteroendocrine, immune, and neuronal cells, while butyrate also acts as a histone deacetylase inhibitor directly linking microbial metabolism to host gene regulation

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The semaglutide segment dominated the market with a major share of 46% in 2025 because of its robust clinical efficacy in glycemic control and weight loss, which is backed by a wealth of empirical data