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Its small-molecule candidate danuglipron showed promising efficacy, with placebo-adjusted weight reductions of 813% in Phase 2b trials

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The pellet was subsequently washed with 10 ml of the G-solution, which comprised of 500 ml HBSS (BE10-508F, Life Technologies) with 10% BSA (126615, Sigma Aldrich) and 1% Pen-Strep (15140122, Life Technologies), and re-suspended in 5.5 ml of gradient solution (15% Optiprep (5 ml 10% RPMI, Life Technologies) + 3 ml of 40% Optiprep, which was diluted from 60 % Optiprep with G-solution (D1556, Sigma Aldrich)) per sample, and placed on top of 2.5 ml of the gradient solution

Wong CYJ, Baldelli A, Hoyos CM et al (2024) Insulin delivery to the brain via the nasal route: unraveling the potential for Alzheimers disease therapy