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Nejman, D
Metformin promoted mitochondrial biogenesis by inhibiting PDK4, thereby suppressing VSMC osteogenesis [202]
In the situation of HF in people with type 2 diabetes, the SGLT2 inhibitor could be used alongside metformin at the point of diagnosis of type 2 diabetes as described above for atherosclerotic heart disease or if HF is diagnosed at any point subsequently (NICE, 2022a)
doi:10.1111/dom.14831 175
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