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Hypothesis 4 Body composition Retatrutide's glucagon-receptor activation drives some of its weight loss through increased energy expenditure, which is mechanistically associated with sparing more lean mass than pure-satiety pathways
CagriSema, developed by Novo Nordisk, is a fixed-dose combination of cagrilintide (a long-acting amylin analog) and semaglutide (a GLP-1 receptor agonist)
The fact that retatrutide passed its Phase 1 and Phase 2 trials means researchers deemed it safe enough for large-scale human testing
Cell 13 , 867878 (2004)
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