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GHK-Cu is a complex naturally present in human plasma at a concentration of approximately 200 ng/mL at age 20, declining to ~80 ng/mL at age 60
these changes do not make it a growth-hormone secretagogue, instead they sharply reduce its binding to IGF-binding proteins (IGFBPs), which is what extends its circulating half-life and potency relative to native IGF-1
Reactive oxygen species (ROS), produced via GSH-mediated pathways, can serve as danger-associated molecular patterns, stimulating dendritic cells and promoting T-cell expansion [82]
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