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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

Since CagriSema contains semaglutide rather than tirzepatide, the transition involves switching GLP-1 agonists while adding an amylin component

The GLP-1 injection site guide and GLP-1 injection technique guide cover the fundamentals

Research involving Cagrilintide focuses on its interaction with amylin-related pathways involved in appetite regulation and metabolic function