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As iron deficiency often coexists with lead intoxication, this interaction can produce particularly serious medical complications in children (Piomelli et al., 1987)
It signals the pituitary gland to release a pulse of growth hormone
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Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]
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