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This designation allows the use of this chemical strictly for in-vitro laboratory testing and experimentation
Metformin has anti-inflammatory and immunomodulatory properties in various immune-related diseases through AMPK-dependent and AMPK-independent mechanisms involving both the innate and adaptive immune systems
doi: 10.1016/j.intimp.2006.08.015 173 ChakravorttyDKoideNKatoYSugiyamaTMuMMYoshidaTet al
These in-organ changes in energy metabolism are also reflected in the plasma metabolome after ischemic AKI, which is characterized by the depletion of numerous amino acids and energy substrates 6
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