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In airway epithelial cells and alveolar macrophages exposed to CSE, PINK1-Parkin-mediated mitophagy enhances the clearance of damaged mitochondria, reduces mitochondrial reactive oxygen species (mtROS) and mtDNA leakage, thereby weakening the second signal of the NLRP3 inflammasome, inhibiting Caspase-1 activation and GSDMD-mediated pyroptosis (197, 198)
The age of eat less and move more has given way to the era of hormone-directed weight management , driven by injectable peptides like semaglutide, liraglutide, and tirzepatide
Many patients report deeper, more restorative sleep a critical factor in recovery, immune function, and overall health
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