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The National Institute on Aging-Alzheimers Association diagnostic guidelines [65], The Dementia Rating Scale-2 [66], International Classification of Diseases 10th Revision [67], and the Consortium to Establish a Registry for Alzheimers Disease [68] neuropsychological battery were used in 5 GSH studies, respectively [31, 37, 48, 50, 59]

Reported incidences included nausea (5.922.2%), diarrhea (8.825.3%), vomiting (2.99.1%), and constipation (8.816.2%), with discontinuation rates reaching 19% in high-dose monthly regimens (816 mg) [62,63,64]

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