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These medications carry a boxed warning regarding thyroid C-cell tumor risk observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
10.3389/fped.2021.650624 80
They were kept at constant environmental conditions throughout the experimental period with a room temperature ranging from 20 to 26C with regular light cycles of 12/1210/14 h light/dark, relative humidity at the level of rat cages of 4070% with room ventilation rates of about 1520 air changes/h
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