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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

Front Pharmacol (Internet) 6, 286.CrossRefGoogle ScholarPubMed Zhai, Z, Fu, Y, Zhang, X, et al

The 8013 hyperinvasive meningococcus strain remains trapped and survives in the mucus layer in Calu3 grown on ALI (Peters et al., 2024), suggesting the use of a transcellular route

Administration Depending on current best practices, treatment may be via injection or other medically approved delivery