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Enhanced Protocol: REDEFINE Clinical Titration The clinical trial program uses a structured 16-week titration to the full therapeutic dose: This clinical protocol is the evidence-based approach used in REDEFINE trials
In addition, HGF induction of the c-MET receptor causes stimulation of cell motility and cellcell aggregation of NCI-H69 cells in culture, correlating with induction of tyrosine phosphorylation of a number of focal adhesion proteins such as paxillin, FAK, and PYK2 (Maulik et al, 2002a)
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Most researchers ask the question thinking they want the first answer, but protocol success depends on the third
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