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However, kidney disease can affect drug metabolism and elimination, and tirzepatide is primarily eliminated via proteolytic degradation rather than renal clearance, which means dose adjustments for kidney function are generally not needed

Gastrointestinal side effects are typically most pronounced during the initial weeks of treatment and following dose increases

If the liquid appears cloudy, discoloured (yellowish or brownish), or contains particles, crystals, or flakes, the pen should be discarded immediately

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