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Providers should also review patient histories for: Metalloprotein disorders Kidney or liver impairment Preexisting inflammatory conditions Are There Side Effects to Topical GHK-Cu

Discussion Resmetirom was approved by the FDA as the first and thus far only MASH therapeutic drug, and the GLP-1 analog semaglutide showed positive effects in patients with MASH in a phase III clinical trial 35

Whether the additional glucagon receptor activity in retatrutide meaningfully alters the gastrointestinal side-effect profile compared with single or dual agonists has not been established in head-to-head studies, and such comparisons should be interpreted with caution