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These data imply that in the mammalian axons of the adult brains, presynaptic mitochondria are probably not the main source of ATP

1 Introduction Parkinsons disease (PD) ranks as the second most common neurodegenerative disorder, primarily manifesting through hallmark motor symptoms such as tremor, bradykinesia, postural instability, and rigidity, with non-motor symptoms including sleep disturbances, olfactory deficits, cognitive impairments, and depression often predating the motor manifestations (Madiha et al., 2021)

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