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The most common side effects Nausea and a feeling of early satiety Vomiting Diarrhoea or constipation Abdominal pain/heavy feeling, bloating, acid reflux Loss of appetite (sometimes excessive) Contraindications and risks to be aware of Possible problems with the gallbladder or bile ducts in some people (particularly with rapid weight loss) Caution is advised in people who have had pancreatitis or who have symptoms suggestive of it (always to be assessed by a doctor) Risk of hypoglycaemia when used in combination with insulin or sulphonylureas (a dose adjustment may be necessary) Interactions with oral medicines: delayed gastric emptying may affect the absorption of certain medicines Thyroid-related issues: the PRAC/EMA concluded that the available evidence does not support a causal link between the GLP-1 receptor agonists assessed and thyroid cancer, although monitoring and appropriate use remain important Frequently asked questions What exactly is the GLP-1 hormone

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