These reductions often correlate with decreased hepatic steatosis as measured by imaging studies or liver biopsy
Manfredi Rizzo is former Director, Clinical Medical & Regulatory Department, Novo Nordisk Europe East and South and has given lectures, received honoraria and research support, and participated in conferences, advisory boards and clinical trials sponsored by pharmaceutical industry including Amgen, AstraZeneca, Boehringer Ingelheim, Kowa, Eli Lilly, Meda, Mylan, Merck Sharp & Dohme, Novo Nordisk, Novartis, Roche Diagnostics, Sanofi and Servier
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The improvement in lipid metabolism and immune function was further confirmed in companion publications by the same research group, which showed connections between global DNA methylation and its effect on proliferator-activated receptor alpha (PPAR) (Osorio et al., 2016)