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More than a third lost 20% of body weight
Diarrhea affects 16-34% of retatrutide users depending on dose, making it the second most common GI side effect after nausea
The fixed-dose approach, particularly the high dose of oral semaglutide may not sound practical especially in daily clinical practice
According to Grigson, Because our preliminary data suggested that patients did better in the study if they were on both the GLP-1 drug and medication for opioid use disorder, in this study, half of the participants will be on methadone and half will be on buprenorphine for opioid use disorder treatment. Because semaglutide is stronger, is dosed weekly instead of daily, and has fewer gastrointestinal side effects than liraglutide, it may be even more effective in reducing craving while increasing real-world treatment adherence
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