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Switching off retatrutide back to a less aggressive GLP-1 is also expected for patients who cant tolerate the glucagon-driven side effect profile
[Accessed 26/01/2026]
FIGURE 2 Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis results of differentially expressed genes The results of GO analysis showed that the molecular functions of differential genes mainly included pseudouridine synthase activity, BMP receptor binding, xylosyltransferase activity, proton antiporter activity (sodium, monovalent cation, potassium), calcium-dependent protein kinase activity, low-density lipoprotein particle receptor activity, transferase activity, and transferring glycosyl and pentosyl groups
It sensitizes tumors by inhibiting PARP1-mediated autophagy while reducing cisplatin-induced organ damage
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