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In the context of a potential therapy for NASH, stabilization against FAP degradation is noteworthy because expression of FAP is greatly elevated in liver from NASH patients compared to appropriate control liver (297)

Medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) are helping patients achieve levels of weight loss that were previously difficult to attain without bariatric surgery

Wegovy can interact with (not limited to): diabetes medications sulfonylureas, metformin and linagliptin antidepressants fluxetine and tranlycypromine ACE inhibitors losartan and valsartan thyroid medication levothyroxine Wegovy can sometimes interact with certain antibiotics

Improved Metabolic Health: Beyond weight loss, semaglutide can help improve blood sugar levels, reduce blood pressure, and lower the risk of developing chronic diseases associated with obesity