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After systemic administration, they engage both GLP1R and GIPR simultaneously in native tissue, enabling the study of receptor engagement, metabolic responses, and therapeutic effects at the cellular and organ level, going beyond localization to provide functional readouts directly in living models
Similar to black pigment stones, brown pigment stones are shaped in situations of biliary stasis and infection, regularly containing cholesterol and other bile additives together with calcium bilirubinate [36]
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