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Combining cagrilintide with tirzepatide could theoretically produce 20-30% body weight loss by targeting three distinct pathways (GIP, GLP-1, and amylin), but the lack of clinical data means dosing protocols are speculative, side effect profiles unknown, and safety unclear
For obese individuals with T2DM a decrease in weight of 510% is clinically significant and is associated with improvements in cardiovascular risk factors (102)
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