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Individuals were included in the study if they had been diagnosed with type 2 diabetes and tobacco use disorder but had not used any medications for diabetes in the past year and had one or more diseases such as hypertension, hyperlipidemia, obesity, hypercholesterolemia, stroke, or heart disease

Recognition of this has spurred a number of innovative approaches that, despite their preclinical promise, have yielded disappointing efforts at translation into a meaningful clinical role

Stress regulation

Some individuals view lower doses as a way to support short- or medium-term metabolic goals rather than committing to higher doses long term