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Specific Clinical Relevance Osteoarthritis GLP-1's primary advantage in OA is its dual capacity to modulate synovial macrophage polarization (M1M2) while directly inhibiting cartilage matrix-degrading enzymes (MMP-3, MMP-13, ADAMTS-4/5) and promoting COL2 and aggrecan synthesis

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Our analyses demonstrated that, despite significant downregulation of canonical melanization-related genes that was validated by qRT-PCR (Supplementary Fig

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