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2.1.2 Dysregulation of key iron-regulating proteins In ferroptosis, intracellular iron homeostasis is maintained by a network of regulatory mechanisms, including iron acquisition via the transferrin (Tf)/transferrin receptor 1 (TfR1) pathway, intracellular transport by divalent metal transporter 1 (DMT1), export by ferroportin (FPN1), storage in ferritin, and iron release through ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4) (39, 40)

Casilla-Lennon MM, Meltzer-Brody S, Steiner AZ

Fever, chills, and redness, pus or spreading warmth at the site can indicate cellulitis or a bloodstream infection and need medical attention