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After the cross-linking reaction is completed, PBS solution is added for washing and then centrifuge to remove the unbound RBITC, thereby obtaining the RBITC-GLP-1RAs@NPs and RBITC-GLP-1RAs@NPs-WYRGRL precipitates

GLP-1 receptor activation primarily works through appetite suppression, slowed gastric emptying, and improved glucose metabolism

Most individuals who experience sleep problems notice them during the first few weeks of treatment, and symptoms often improve as the body adjusts