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In response to chemical stress, keratinocytes produce and release inflammatory cytokines, chemokines and other signaling markers that rapidly generate cutaneous inflammation 35
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Notably, GHKs gene expression signature was found to reverse 70% of the genes in a signature for metastasis-prone colon cancer (Hong et al.), and to shift gene expression in COPD lung tissue from a destructive/inflammatory pattern toward healthy remodeling
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