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They conducted an observational study in which they enrolled 92 individuals undergoing this type of therapy at four institutions in the Gifu Prefecture, Japan
Microscopic examination of the permanent sections revealed a well-circumscribed, heavily pigmented neoplasm, arranged in nests and composed of epithelioid cells with round nuclei and prominent nucleoli, with admixed melanophages (Figure 3A)
A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases
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