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The effect of sleep and shift work on the primary immune response to messenger RNA-based COVID-19 vaccination
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As PVR is an avascular disease lacking neovascularization, VEGF primarily promotes ECM deposition and fibrotic membrane formation by regulating the activity of RPE cells, fibroblasts, and transdifferentiated myofibroblasts ( 4.2 Expression of inflammatory cytokines and their related pathways In the early stages of injury, TNF- is upregulated as a key inflammatory cytokine, leading to immune cell recruitment and promoting the activation of retinal cells ( In addition to TNF-, the release of several inflammatory cytokines such as IL-6, IL-8, IL-10, IL-1, and IFN- significantly promotes the development of PVR ( In vitro , IL-6 significantly induces RPE cell proliferation and EMT in a dose-dependent manner, accompanied by rapid phosphorylation of JAK1 and STAT3 ( Table 1 , a wide array of cytokines and growth factors, derived from diverse cellular sources, orchestrate the complex pathophysiology of PVR
And the effect only lasts when people are taking the drug, meaning that they potentially need lifelong treatment
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