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[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders
In the landmark SELECT trial, semaglutide 2.4 mg demonstrated a 20% relative risk reduction in major adverse cardiovascular events in over 17,000 patients with obesity but without diabetes
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