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Pyruvate kinase M2 is a phosphotyrosine-binding protein
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Pickart 2015 BioMed Res Int sequenced by Affymetrix chip the effects of 10 nM GHK-Cu on human fibroblasts after 24h: 4192 significantly modulated genes, including activation of DNA repair programmes (NBN, BRCA1), regeneration (collagens, elastin, integrins), antioxidant defence (glutathione peroxidase, SOD, peroxiredoxins) and anti-inflammatory modulation (reduction of TNF-alpha, IL-6, IL-8)
4 Despite its central role in mitochondrial fatty acid oxidation and metabolic homeostasis, the molecular regulation and physiological significance of endogenous carnitine biosynthesis, as well as the identity of the initial transporter that introduces the precursor TML into this pathway, remain incompletely understood
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