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A general pattern: Cardiovascular outcomes: semaglutide has stronger evidence Weight loss and glucose control: orforglipron is competitive and sometimes leads Convenience: orforglipron is simpler to use Medicare coverage If you have Medicare, you can get a pharmacy benefit card to buy Foundayo for $50 a month
However, this meta-analysis included only one RCT 43 and one case-control study 51 for GLP-1RAs (but not the more recent semaglutide) 41
BMJ 339:b2700b2700
More Gastrointestinal Adverse Events Researchers in Canada conducted a study to compare the safety outcomes of GLP-1 like Semaglutide
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