Specifically, the biosynthesis of amino acids (37 KOs), was significantly down-represented, including cysteine and methionine metabolism ( metA , metB , metK , mtnN , thrB , cysK , patB and L-serine dehydratase ), the biosynthesis of lysine ( dapA , dapB , dapE , dapH , dapL , argD , patA and lysA ), the metabolism of histidine ( hisA , hisB , hisE , hisH and hisI ), glycine, serine and threonine ( glyA , thrB , thrC and L-serine dehydratase ), alanine, aspartate and glutamate (asnA, asnB and argH), the biosynthesis of phenylalanine, tyrosine and tryptophan ( aroD and aroE ) and the biosynthesis of arginine ( argD and argH )
The authors noted limitations including reliance on ICD codes to identify NAION, lack of data on diabetes duration prior to Medicare enrollment, and a restricted age range that may limit generalizability
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Companion Supplies & Routine Support DSIP Dosage Chart This DSIP dosage chart summarizes the IV trial context and SubQ research-planning ranges from 100 mcg to 300 mcg shown in the dosing section above