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We do not have reliable dose thresholds that predict when a typical adult will produce clinically relevant TMA from L-carnitine
Follow-up labs are typically rechecked at the end of a cycle to assess response
[2] At a clinically-supported dose of 4 grams, L-citrulline can significantly increase plasma arginine concentrations, leading to improved blood flow and muscle pumps during exercise
Evidence strength depends on study design, directness, replication, sample size, and whether researchers measured a meaningful outcome
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