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The expression of GLS-2 is also positively regulated by wild-type TP53 , as such the conversion of glutamine-to-glutamate increases, which is requisite for supplement of NADPH and GSH (172, 173)
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Ferroptosis is precisely controlled via a regulatory network involving the inhibitory role of glutathione peroxidase 4 (GPX4) and cystine transporter SLC7A11 (system X c - , xCT)
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