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However, despite these substances are able to interfere with iodine uptake in the thyroid, the consumption of reasonable amounts of foods containing goitrogens is not a concern for people who have adequate iodine intakes and eat a variety of foods, and there are no contraindications to their consumption, as detailed below [53]

Bian: Randomized clinical trials are the gold standard

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Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc