Despite some promising data, ibutamoren was banned for use in compounding pharmacies by the FDA (8) during the 2023 episode, but unlike ipamorelin and others, it currently remains banned due to concerns for heart failure
We previously showed that GIPR activity in alpha cells potentiates amino-acid-stimulated glucagon secretion in mouse islets 11 , and here we found the same interaction between hGIP and amino acids in human islets using concentrations of amino acids found in the postprandial state (Extended Data Figure 4) 11 , prompting us to ask whether tirzepatide engagement of the GIPR in human islets also enhances the effect of amino acids on glucagon secretion
1: Semenistaya E, Zvereva I, Thomas A, Thevis M, Krotov G, Rodchenkov G
and US Chem Labs to stop selling non-FDA approved semaglutide and tirzepatide, the active ingredients in the diabetes treatments Ozempic and Mounjaro