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Through increased labeling of BCKA-derived metabolites and increases in levels of BCAA breakdown, such as glutamate, alanine, and 3-hydroxyisobutyric acid, they discovered that tirzepatide treatment stimulated catabolism of BCAAs/BCKAs in BAT
It mimics the 'hunger hormone' ghrelin at its receptor in the pituitary gland, triggering a clean pulse of growth hormone release
However there are two separate pools of carnitine that need to be utilized to move fatty acids into the mitochondria
The effect size was robust (Hedges g = 0.98), indicating a pronounced depletion in antioxidant capacity in this region
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