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Stubborn fat deposits that resist diet and exercise, difficulty with body recomposition, patients on a weight management program who want additional metabolic support, and those seeking fat-targeted peptide therapy without broad hormonal effects
At the mechanistic level, PQQ was found to promote the upregulation of Yes-associated Protein (YAP), to suppress YAP phosphorylation, and to drive the nuclear translocation of YAP within hypertrophic cardiomyocytes
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