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Admittedly, lactate has been found to participate in various energy activities typical of glycolytic metabolism, despite excessive oxygen consumption, due to the heterogeneity of neurocytes with distinct metabolic features within the central nervous system, such as astrocytes [182]
It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig
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