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Molecular and functional effects of the novel MEK inhibitor PD0325901 in preclinical models of human leukemias
Studies prove it works
For these reasons, while inhibiting LRRK2 kinase activity is considered a promising neuroprotective strategy in PD, primarily by reducing -syn-mediated inflammation, there are concerns regarding off-target systemic effects
While the short-term benefits may seem appealing, the long-term risks are too significant to ignoreespecially when safer, better-understood alternatives are available
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